Rulide

Semisynthetic macrolide antibiotic for oral administration. Sensitive to the drug: Streptococci! Groups A and B, including Str. pyogenes, Str. agalactiae, Str. mitis, saunguis, viridans, Streptococcuspneumoniae; Neisseriameningitidis; Moraxellacatarrhalis; Legionella; Bordetellapertussis; Listeriamonocytogenes; Corynebacteriumdiphtheriae; Clostridium; Mycoplasmapneumoniae; Pasteurellamultocida; Ureaplasmaurealyticum; Chlamidiatrachomatisi psittaci; Legionellapneumophilia; Campylobacter; Gardnerellavaginalis.

Go to the drug sensitive impermanent: Staphylococ-cusaureusi epidermidis; Haemophilusinfluenzae; Bac-teroidesfragilisi Vibrocholerae. For drug resistant: Enterobacteriaceae, Pseudomonas. 'Akinetobakter.

Indications

Treatment of susceptible infections, including infections of the upper and lower respiratory tract infections of skin and soft tissue, urinary tract infections (including sexually transmitted diseases through, gonorrhea), prevention of meningococcal meningitis (purulent inflammation of the meninges) in people who were in contact with the diseased.

How to use

Before assigning the patient the drug is desirable to determine the sensitivity to microorganisms that caused the disease in this patient. Adults appoint 0.15 g of the drug 2 times a day, morning and evening, before meals. In the case of liver failure drug is prescribed at a dose of 0.15 g 1 per day. In appointing the drug to patients with liver failure need special care, monitoring of liver function and dose adjustment.

In appointing the drug to patients with renal insufficiency and elderly patients need a dose adjustment does not arise.

Joint application with the derivatives ergotamine and ergotaminopodobnymi vasoconstrictive agents is not allowed, since it may lead to ergotism (poisoning by ergot alkaloids) and necrosis (necrosis) of tissue of the limbs.

In an application with bromocriptine may increase the concentration of drug in plasma and increased egoantiparkinsonicheskogo action or dopamine toxicity (dyskinetic / breaches of the mobility /).

In an application with cyclosporine reduce the dose and monitor kidney function as possible to increase the concentration of this drug in the blood (due to the inhibition of its metabolism) and creatinine (the end product of nitrogen metabolism) in the blood.

Side effects

Nausea, vomiting, abdominal pain, diarrhea, transient (prshodyashss) increased level of transaminases and alkaline phosphatase (enzyme), allergic reaction.

Contraindications

Increased sensitivity to antibiotics, macrolides, co-administration of drugs such as ergotamine and dihydroergotamine, pregnancy and lactation. The drug should be prescribed with care to patients with an indication of the allergic reactions in the anamnesis (case history).

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